Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals
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- 作者：Inke L¨¹hr ; Andreas Friedl ; Thorsten Overath ; Andreas Tholey ; Thomas Kunze ; Felix Hilpert ; Susanne Sebens ; Norbert Arnold ; Frank R?sel ; Hans-Heinrich Oberg ; Nicolai Maass ; Christoph Mundhenke ; Walter Jonat ; Maret Bauer
- 关键词：Mammary fibroblasts ; Microenvironment ; Breast cancer ; Acinar morphogenesis ; Matrix compliance
- 刊名：Cancer Letters
- 出版年：2012
- 出版时间：28 December, 2012
- 年：2012
- 卷：325
- 期：2
- 页码：175-188
- 全文大小：1785 K
文摘
Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of epithelial cell morphogenesis. Readjustment of matrix tension by fibroblasts can even induce a phenotypic reversion of breast carcinoma cells. These data offer a basis to develop new strategies for the normalization of the tumor stroma as an innovative target in cancer therapy.