New PCOS-like phenotype in older infertile women of likely autoimmune adrenal etiology with high AMH but low androgens

详细信息    查看全文

• 作者：Norbert Gleicher^a ; ^b ; ^c ; ^d ; ^{ngleicher@thechr.com} ; ^{ngleicher@rockefeller.edu} ; ^{ykizawa@thechr.com} ; Vitaly A. Kushnir^a ; ^e ; Sarah K. Darmon^a ; Qi Wang^a ; Lin Zhang^a ; David F. Albertini^a ; ^c ; David H. Barad^a ; ^b
• 关键词：ACTH ; adrenocorticotrophic hormone ; AI ; adrenal insufficiency ; AMH ; anti-Mü ; llerian hormone ; AR ; androgen receptor ; C ; cortisol ; CP ; clinical pregnancies ; CRP ; C-reactive protein ; DHEA ; dehydroepiandrosterone ; DHEAS ; dehydroepiandrosteroen sulphate ; FSH ; follicle stimulating hormone ; FOR ; functional ovarian reserve ; GCs ; granulosa cells ; hMG ; human menopausal gonadotropin ; Ig ; immunoglobulin ; IL-6 ; interleukin 6 ; IVF ; in vitro fertilization ; LB ; live births ; PCOS ; polycystic ovary syndrome
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：144-152
• 全文大小：464 K
• 卷排序：167

文摘

We discovered a previously unknown hyo-androgenic polycystic ovary syndrome (PCOS) phenotype. Its hypo-androgenism appears adrenal in origin, representing insufficiency of the zona reticularis. Since closely associated with anti-thyroid autoimmunity, it, likely, is also autoimmune in etiology. This, therefore, suggests that, like the other two zonae, the zona-reticularis can also be affected by autoimmunity. Adrenal hypo-androgenism, therefore, has to be considered a potential component of autoimmune adrenal insufficiency.