Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons
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- 作者：C. Ardiantoa ; N. Yonemochia ; S. Yamamotoa ; L. Yanga ; F. Takenoyab ; S. Shiodac ; H. Nagased ; H. Ikedaa ; h-ikeda@hoshi.ac.jp" class="auth_mail" title="E-mail the corresponding author ; J. Kameia
- 关键词：3-MP ; 3-mercaptopropionic acid ; AgRP ; agouti-related peptide ; ANOVA ; analysis of variance ; LH ; lateral hypothalamus ; MCH ; melanin-concentrating hormone ; NAcc ; nucleus accumbens ; norBNI ; norbinaltorphimine ; NPY ; neuropeptide Y ; POMC ; proopiomelanocortin ; PPORX ; preproorexin ; Pro-MCH ; pro-melanin-concentrating hormone ; RT-PCR ; reverse transcription-polymerase chain reaction ; VMH ; ventromedial nucleus of the hypothalamus ; VTA ; ventral tegmental area ; α-MSH ; α-melanocyte-stimulating hormone ; β-FNA
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：320
- 期：Complete
- 页码：183-193
- 全文大小：1386 K
文摘
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The role of opioid receptors in the LH in feeding behavior was examined.
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Inhibition of opioid receptors in the LH suppressed feeding behavior.
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Inhibition of opioid receptors decreased hypothalamic mRNA level of preproorexin.
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Inhibition of opioid receptors increased GABA level in the LH.
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Inhibition of μ and κ opioid receptors blocked feeding via GABA and orexin neurons.