Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties

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• 作者：Jessica  ; Nilsson^a ; Albert A.  ; Shteinman^b ; Eva  ; Degerman^c ; Eva A.  ; Enyedy^d ; Tamá ; s  ; Kiss^d ; Ulrich  ; Behrens^e ; Dieter  ; Rehder^e ;   ; ^{rehder@chemie.uni-hamburg.de} ; Ebbe  ; Nordlander^a ;   ; ^{Ebbe.Nordlander@chemphys.lu.se}
• 关键词：Vanadium ; Insulin mimicry ; Diabetes
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：105
• 期：12
• 页码：1795-1800
• 全文大小：455 K

文摘

Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H₂papy) with VOSO₄ in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}₂ ¦Ì-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H₂glysal) with VOSO₄ gives [(glysal)VO(H₂O)] (2) and reaction of salicylamide (Hsalam) with VOSO₄ in methanol gives [(salam)₂VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2?0. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.