Continuous Norethisterone Acetate versus Cyclical Drospirenone 3 mg/Ethinyl Estradiol 20 μg for the Management of Primary Dysmenorrhea in Young Adult Women

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• 作者：Moamar Al-Jefout ; MD ; PhD¹ ; ^{drmoamar@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author} ; Nedal Nawaiseh ; MD ; PhD²
• 关键词：Primary dysmenorrhea ; Young adult women ; Norethisterone acetate ; Combined oral contraceptive pill
• 刊名：Journal of Pediatric and Adolescent Gynecology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：29
• 期：2
• 页码：143-147
• 全文大小：216 K

文摘

To evaluate the efficacy of continuous norethisterone acetate (NET-A), 5 mg (group N) vs cyclical combined oral contraceptive pill (COC) consisting of drospirenone 3 mg/ethinyl estradiol 20 μg pills (group P) in treating dysmenorrhea in young adult women.

Design, Setting, and Participants

This prospective, open-label, nonrandomized study included 38 Jordanian patients: 20 patients in group N and 18 patients in group P.

Interventions

Continuous NET-A 5 mg daily or cyclical COC.

Main Outcome Measures

Pain scores, adverse effects, analgesic use, school absence, and cost.

Results

Thirty-eight patients used NET-A or COC for 6 months. All participants had almost the same starting levels of visual analogue scale (VAS) scores. Both drugs were similar in suppressing dysmenorrhea at the 3-month follow-up visit; VAS score mean (±SD) in group N and P were 1.30 ± 1.22 and 1.28 ± 0.83 (P = .22), respectively, and after 6 months, with mean VAS scores (±SD) of 1.30 ± 1.22 and 1.28 ± 0.83, respectively (P = .95). The cost of the treatment in the N group was much less than in the P group. Participants in the N group were less likely to use pain killers: 20% and 44% in the N and P groups, respectively (P = .006) in the first month and only 5% and 17% (P = .019) in the N and P groups, respectively, at the 3-month follow-up, and none of them used any analgesics at the 6-month follow-up.

Conclusion

A continuous NET-A regimen is a well tolerated, effective, and inexpensive option for dysmenorrhea treatment and was as good as COC.