Iodine-catalyzed one-pot decarboxylative aromatization of tetrahydro-β-carbolines

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• 作者：Ramu Meesala^a ; ^{Ramumeesala@imu.edu.my} ; Ahmad Saifuddin Mohamad Arshad^b ; Mohd Nizam Mordi^b ; Sharif Mahsufi Mansor^b
• 关键词：β-Carboline ; Decarboxylative aromatization ; Iodine ; Hydrogen peroxide ; Tetrahydro-β-carboline
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：29 December 2016
• 年：2016
• 卷：72
• 期：52
• 页码：8537-8541
• 全文大小：435 K
• 卷排序：72

文摘

A synthetic strategy was developed for the preparation of β-carbolines by one-pot decarboxylation and aromatization of tetrahydro-β-carboline-3-carboxylic acids by employing 10 mol% of iodine in presence of oxidant aqueous H2O2. The method was also successfully extended for the aromatization of tetrahydro-β-carboline-3-methyl esters. The utility of the method was demonstrated in the synthesis of β-carboline alkaloids norharmane, harmane and eudistomin N.