Combination chemotherapy of carboplatin and cytosine arabinoside for high-risk leukemia: a pilot study

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• 作者：Iwao ; Noriaki ; Yoshida ; Minoru ; Hatake ; Kiyohiko ; Hoshino ; Yoshiaki ; Hagiwara ; Shoutaro ; Tomizuka ; Hiroshi ; et. al.
• 关键词：Carboplatin ; cytosine arabinoside ; continuous infusion ; high-risk leukemia ; prolonged neutropenia
• 刊名：Leukemia Research
• 出版年：1995
• 出版时间：December, 1995
• 年：1995
• 卷：19
• 期：12
• 页码：899-903
• 全文大小：421 K

文摘

Fourteen patients with high-risk leukemia (six with relapsed AML, three with relapsed ALL, one with AML-MO, four with CML in myeloid blastic crisis) were treated with a combination chemotherapy of carboplatin (200-300 mg/m²/day) and cytosine arabinoside (100 mg/m²/day) by 24 h continuous infusion for 5-7 days. Five patients (35.7 % ) achieved complete remission including two patients complicated with myelofibrosis (one with AML-M0 and one with CML in myelo-megakaryocytic crisis). Thirteen patients had nausea and vomiting, five patients had severe, prolonged neutropenia for which it was necessary to administer granulocyte colony-stimulating factor and six patients had severe thrombocytopenia. We concluded that this regimen is effective for the treatment of high-risk leukemia.