Antiviral effect of strictinin on influenza virus replication
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- 作者：Repon Kumer Saha ; Tadanobu Takahashi ; Yuuki Kurebayashi ; Keijo Fukushima ; Akira Minami ; Noriaki Kinbara ; Masaki Ichitani ; Yuko M. Sagesaka ; Takashi Suzuki
- 关键词：Strictinin ; Virus ; Influenza ; Parainfluenza ; Antiviral ; Viral entry
- 刊名：Antiviral Research
- 出版年：2010
- 出版时间：October 2010
- 年：2010
- 卷：88
- 期：1
- 页码：10-18
- 全文大小：823 K
文摘
Strictinin, which is a member of the ellagitanin family of hydrolyzable tannins, prevented replication of human, duck and swine influenza A viruses (IAVs) in vitro at non-toxic concentrations. The addition of strictinin at the same time as IAV inoculation to MDCK cells inhibited viral replication in a dose-dependent manner. Strictinin showed 50 % inhibitory concentrations for IAVs from 0.09 ± 0.021 to 0.28 ± 0.037 μM (mean ± S.E.M.) by the focus-forming assay. Treatment of MDCK cells with strictinin before and after viral inoculation resulted in no significant antiviral activity. Further studies showed that strictinin inhibited IAV-induced hemifusion. However, strictinin exhibited no inhibitory effect against receptor binding, sialidase activity. Strictinin also showed an antiviral effect on influenza B virus and human parainfluenza virus type-1 in vitro. The results indicate that strictinin is a useful antiviral agent.