Clinical Outcomes in Descemet Stripping Automated Endothelial Keratoplasty With Internationally Shipped Precut Donor Corneas

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• 作者：Hiroko Nakagawa ; Tsutomu Inatomi ; Osamu Hieda ; Chie Sotozono ; Norihiko Yokoi ; Bernardino Iliakis ; Thomas D. Miller ; Caroline Ulrickson ; Shigeru Kinoshita
• 刊名：American Journal of Ophthalmology
• 出版年：January, 2014
• 年：2014
• 卷：157
• 期：1
• 页码：50-55.e1
• 全文大小：409 K

文摘

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Purpose

To report the endothelial cell loss and clinical outcomes in Descemet stripping automated endothelial keratoplasty (DSAEK) with internationally shipped, precut donor corneas.

Design

Retrospective analysis of a noncomparative case series.

Methods

The setting was a single hospital. The clinical results of 134 eyes of 128 patients who underwent DSAEK in Kyoto, Japan, with internationally shipped precut donor corneas from Portland, Oregon, or Seattle, Washington, were evaluated. In addition, 40 precut donor corneas from Seattle were evaluated in respect to the postprecut international shipment-related loss of corneal endothelial cell density (ECD). Observation procedures were noncontact specular microscopy. The main outcome measures were the evaluation of international shipment-related ECD loss, postoperative ECD, visual recovery, and complications.

Results

The mean postprecut ECD loss in 40 donor corneas during international shipment was 2.3%. The mean elapsed time from cut to surgery was 63.2 卤 31.1 hours. At 6, 12, 24, and 36聽months postoperatively, the mean ECD of the internationally shipped donor corneas was 2038, 1933, 1670, and 1431 cells/mm², respectively. The mean ECD loss at 6, 12, 24, 36聽months after DSAEK was 30%, 34%, 44%, and 51%, respectively. Preoperative logarithm of the minimum angle of resolution (logMAR) best spectacle-corrected visual acuity was 1.40 卤 0.55, and at 12聽months after DSAEK was 0.22聽卤 0.19. Complications included graft dislocation in 12 eyes (8.9%) and graft rejection in 3 eyes (2.2%).

Conclusions

The present study shows that the outcomes of DSAEK with internationally shipped precut donor corneas were acceptable and that the additional endothelial cell loss associated with international shipment was minimal and did not affect the clinical results.