The utility of urinary myo-inositol as a marker of glucose intolerance

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• 作者：Hiroaki Ikezaki ; Norihiro Furusyo ; Kyoko Okada ; Takeshi Ihara ; Takeo Hayashi ; Eiichi Ogawa ; Mosaburo Kainuma ; Masayuki Murata ; Jun Hayashi
• 关键词：Myo-inositol ; Diabetes ; Oral glucose tolerance test
• 刊名：Diabetes Research and Clinical Practice
• 出版年：January, 2014
• 年：2014
• 卷：103
• 期：1
• 页码：88-96
• 全文大小：582 K

文摘

Objective

The most common screening tests for glucose intolerance are fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Because it reflects the current status of hyperglycemia, urinary myo-inositol (UMI) may be useful. We evaluated UMI as a screening tool for glucose intolerance.

Design and methods

A cross-sectional, community-based population study of 1057 Japanese residents. 173 with an FPG level between 5.5 and 6.9 mmol/L and an HbA1c under 6.5% had an oral glucose tolerance test. We measured UMI level before (fasting UMI) and 2 h after (2 h-UMI) glucose ingestion. 螖-UMI was defined as the difference between fasting UMI and 2 h-UMI.

Results

螖-UMI, 2 h-UMI and HbA1c levels significantly increased as glucose intolerance worsened. 螖-UMI level was significantly positively correlated with 2 h-UMI level (r = 0.896, p < 0.001). Using cutoff levels from receiver operating characteristic (ROC) analyses, the sensitivity of 螖-UMI (82.1%) and 2 h-UMI (79.3%) were higher than that of HbA1c (48.3%). The area under the ROC curve values for 螖-UMI (0.903) and 2 h-UMI (0.891) were higher than that for HbA1c (0.785).

Conclusions

2 h-UMI is useful as a non-invasive screening of glucose intolerance.