Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord: Changes in patients with amyotrophic lateral sclerosis

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• 作者：Tatsuya Yamamoto^a ; ^b ; Shigeo Murayama^c ; Masaki Takao^c ; ^d ; ^e ; Tadashi Isa^f ; ^g ; Noriyuki Higo^a ; ^{n.higo@aist.go.jp}
• 关键词：Corticospinal neuron ; Degeneration ; Immunohistochemistry ; Motor neuron ; Primary somatosensory cortex ; Spinal ventral horn
• 刊名：Brain Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1655
• 期：Complete
• 页码：168-175
• 全文大小：1094 K
• 卷排序：1655

文摘

The SPP1 expression in human S1 was weaker than M1. SPP1 was expressed in motor neurons in the human spinal cord. SPP1 may have a role in the specialization of motor projection neurons The expression was reduced in both M1 and the spinal cord of ALS patients. The reduced expression may be implicated in the neurodegeneration seen in ALS.