Reduced sensory stimulation alters the molecular make-up of glutamatergic hair cell synapses in the developing cochlea
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- 作者：M. Barclaya ; R. Constablea ; N.R. Jamesa ; P.R. Thornea ; b ; J.M. Montgomerya ; jm.montgomery@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABR ; auditory brainstem response ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor ; BSA ; bovine serum albumin ; EPSP ; excitatory postsynaptic potential ; GluA ; AMPA receptor subunit ; IgG (H ; + ; L) ; immunoglobulin (Heavy and Light chain) ; IHC ; inner hair cell ; NGS ; normal goat serum ; oC ; organ of Corti ; PBS ; phosphate-buffered saline ; SGN ; spiral ganglion neuron
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：325
- 期：Complete
- 页码：50-62
- 全文大小：2358 K
文摘
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Normal acoustic stimulation is not required for maintenance of afferent innervations.
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Cochlear synapses are subject to activity-dependant plasticity after hearing onset.
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Presynaptic and postsynaptic proteins are affected by reduced acoustic stimulation.