CD4⁺CD25⁺FoxP3⁺ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis

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• 作者：Manoj Kumar ; Norman Putzki ; Volker Limmroth ; Ralph Remus ; Monika Lindemann ; Dietmar Knop ; Norbert Mueller ; Cornelia Hardt ; Ernst Kreuzfelder ; Hans Grosse-Wilde
• 关键词：Multiple sclerosis ; Myelin basic protein ; Proliferation ; Regulatory T cells ; FOXP3
• 刊名：Journal of Neuroimmunology
• 出版年：2006
• 出版时间：November 2006
• 年：2006
• 卷：180
• 期：1-2
• 页码：178-184
• 全文大小：214 K

文摘

Multiple sclerosis (MS) is an autoimmune disorder directed against self antigens of the central nervous system. CD4⁺CD25⁺FoxP3⁺ regulatory T cell (T_reg) mediated suppression is an essential mechanism of self-tolerance. We studied whether changes in the suppressive function of a mixture of CD25^high and CD25^intemediate expressing T_reg cells in myelin basic protein (MBP)-induced proliferation occurred in untreated MS patients. Suppression of MBP-induced proliferation was observed in 13 out of 29 (45 % ) MS patients; this was significantly (p < 0.05) less compared with 17 out of 19 (89 % ) healthy individuals. Relative T_reg counts was significantly increased in MS patients (mean ± S.D.; 20 ± 8 % ) compared with healthy individuals (15 ± 5 % ). These findings suggest that impaired T_reg function may be involved in pathogenesis of MS.