Plasma levels of leptin and orexin A in the restrictive type of anorexia nervosa

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• 作者：Mał ; gorzata Janas-Kozik^a ; ^b ; ^{mkozik@centrum-pediatrii.com.pl"" rel=""nofollow} ; ^{mjkozik@o2.pl"" rel=""nofollow} ; Mał ; gorzata Stachowicz^c ; Irena Krupka-Matuszczyk^a ; Jan Szymszal^d ; Krzysztof Krysta^a ; Adam Janas^e ; Janusz K. Rybakowski^f
• 关键词：Body mass index ; Orexins ; Restrictive type of AN
• 刊名：Regulatory Peptides
• 出版年：2011
• 出版时间：7 June 2011
• 年：2011
• 卷：168
• 期：1-3
• 页码：5-9
• 全文大小：307 K

文摘

Objective

The aim of the study was to analyze the pattern of leptin and orexin A plasma levels in patients with the restrictive type of anorexia nervosa (AN-R), during the course of treatment. Thirty females with AN-R, aged 18.0 ± 1.6 years (mean ± SD), range of 15.5–21.0 years, were investigated before and after 2, 3, and 6 months of treatment, which included a normocaloric diet and cognitive–behavioral psychotherapy. The control group consisted of 20 age-matched, healthy control females.

Results

Before the therapy, both leptin and orexin A plasma levels were significantly lower than in the control group and were negatively correlated. During treatment, leptin levels increased and, after 6 months, showed a correlation with body mass index (BMI). Orexin A levels showed a further decrease during treatment, with no correlation with BMI.

Conclusions

The results corroborate those of other researchers showing a decrease of leptin levels in patients with AN-R and its increase with body mass increment. They may also suggest a possible relationship between leptin and orexin A plasma level patterns in such patients.