Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms
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- 作者：Gustavo H. Oliveira-Paulaa ; Riccardo Lacchinib ; Jose E. Tanus-Santosa ; tanus@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author ; tanussantos@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：3&prime ; -UTR ; 3&prime ; -mRNA untranslated region ; 5&prime ; -UTR ; 5&prime ; -mRNA untranslated region ; ACE ; angiotensin-converting enzyme ; ARB ; angiotensin II receptor blocker ; BH4 ; tetrahydrobiopterin ; cGMP ; cyclic guanosine monophosphate ; NOS3 ; endotelial nitric oxide synthase ; FAD ; flavin adenine dinucleotide ; FMN ; flavin mononucleotide ; NOS2 ; inducible nitric oxide synthase ; IRAG ; phosphorylates 1 ; 4 ; 5 inositoltriphosphate receptor-associated cGMP kinase substrate ; MAZ ; MYC-associated zinc finger
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：584-599
- 全文大小：949 K
文摘
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Nitric oxide (NO) is very important in physiology and pathophysiology.
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In the cardiovascular system, most NO is synthesized by endothelial NO synthase (NOS3).
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The NOS3 gene exhibits a number of polymorphic sites.
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Some NOS3 polymorphisms have functional and clinical implications.
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NOS3 polymorphisms affect disease susceptibility and drug responses.