Psychosocial correlates of sleep quality and architecture in women with metastatic breast cancer

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• 作者：Arianna Aldridge-Gerry ; Jamie M. Zeitzer ; Oxana G. Palesh ; Booil Jo ; Bita Nouriani ; Eric Neri ; David Spiegel
• 关键词：Metastatic breast cancer ; Polysomnography ; Sleep quality ; Sleep architecture ; Depression ; Women
• 刊名：Sleep Medicine
• 出版年：November, 2013
• 年：2013
• 卷：14
• 期：11
• 页码：1178-1186
• 全文大小：411 K

文摘

Background

Sleep disturbance is prevalent among women with metastatic breast cancer (MBC). Our study examined the relationship of depression and marital status to sleep assessed over three nights of polysomnography (PSG).

Methods

Women with MBC (N = 103) were recruited; they were predominately white (88.2%) and 57.8 卤 7.7 years of age. Linear regression analyses assessed relationships among depression, marital status, and sleep parameters.

Results

Women with MBC who reported more depressive symptoms had lighter sleep (e.g., stage 1 sleep; P < .05), less slow-wave sleep (SWS) (P < .05), and less rapid eye movement (REM) sleep (P < .05). Single women had less total sleep time (TST) (P < .01), more wake after sleep onset (WASO) (P < .05), worse sleep efficiency (SE) (P < .05), lighter sleep (e.g., stage 1; P < .05), and less REM sleep (P < .05) than married women. Significant interactions indicated that depressed and single women had worse sleep quality than partnered women or those who were not depressed.

Conclusion

Women with MBC and greater symptoms of depression had increased light sleep and reduced SWS and REM sleep, and single women had worse sleep quality and greater light sleep than married counterparts. Marriage was related to improved sleep for women with more depressive symptoms.