Low-dimensional compounds containing bioactive ligands. V: Synthesis and characterization of novel anticancer Pd(II) ionic compounds with quinolin-8-ol halogen derivatives

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• 作者：Peter Vranec ; Ivan Poto膷艌谩k ; Danica Sabolov谩 ; Veronika Farkasov谩 ; Zuzana Ip贸thov谩 ; Jana Pisar膷铆kov谩 ; Helena Paul铆kov谩
• 关键词：Palladium(II) complexes ; Quinolin-8-ol halogen derivatives ; Crystal structure ; DNA binding ; Cytotoxicity
• 刊名：Journal of Inorganic Biochemistry
• 出版年：February, 2014
• 年：2014
• 卷：131
• 期：Complete
• 页码：37-46
• 全文大小：1527 K

文摘

Three novel palladium(II) complexes, NH₂(CH₃)₂[PdCl₂(CQ)] (1) (CQ = 5-chloro-7-iodo-quinolin-8-ol), NH₂(CH₃)₂[PdCl₂(dClQ)] (2) (dClQ = 5,7-dichloro-quinolin-8-ol) and NH₂(CH₃)₂[PdCl₂(dBrQ)] (3) (dBrQ = 5,7-dibromo-quinolin-8-ol) have been prepared and characterized. Their structures contain square-planar [PdCl₂(XQ)]^{鈭?/sup> complex anions in which deprotonated XQ ligands are coordinated to the Pd atoms via the pyridine nitrogen and the phenolato oxygen atoms, other two cis-positions are occupied by two chlorido ligands. Negative charges of these anions are balanced by uncoordinated dimethylammonium cations. Coordination of the XQ ligands to Pd(II) atom was confirmed by the differences in the stretching 谓(Oipt>ipt>H) and 谓(Cipt>ipt>N) vibrations in the IR spectra of ligands and prepared complexes while bands of aliphatic Cipt>ipt>H and Nipt>ipt>H stretching vibrations observed in the spectra of 1-3 confirm the presence of dimethylammonium cations in the complexes. The binding of complexes 1-3 to calf thymus DNA was investigated using UV-visible and fluorescence emission spectrophotometry. The fluorescence spectral results indicate that the complexes can bind to DNA through an intercalative mode. The Stern-Volmer quenching constants obtained from the linear quenching plot are in the 1.04 脳 104 to 4.35 脳 104 M鈭?#xA0;1 range. The complexes exhibit significant anticancer activity tested on A2780 cells and cisplatin resistant cell line A2780/CP.}