‘One-component’ ultrathin multilayer films based on poly(vinyl alcohol) as stabilizing coating for phenytoin-loaded liposomes
详细信息 查看全文
- 作者：Katarzyna Zasada ; Magdalena Łukasiewicz-Atanasov ; Katarzyna Kłysik ; Joanna Lewandowska-Łańcucka ; Barbara Gzyl-Malcher ; Agnieszka Puciul-Malinowska ; Anna Karewicz ; karewicz@chemia.uj.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Maria Nowakowska
- 关键词：Poly(vinyl alcohol) derivative ; Multilayer film ; Phenytoin ; Liposome ; Coating
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：135
- 期：Complete
- 页码：133-142
- 全文大小：1502 K
文摘
- •
New derivatives of poly(vinyl alcohol) (PVA) were synthesized and characterized.
- •
The obtained PVA-based polyelectrolytes self-organize forming multilayer films.
- •
Multilayer film was successfully used to stabilize phenytoin-containing liposomes.
- •
Obtained liposomes show increased ability to penetrate model lipid monolayer.
- •
The proposed system may be an attractive alternative for phenytoin delivery.