Peroxiredoxin6 (Prdx6) binds to the SH3 domain of Nox activator 1.
Prdx6 assembles with the NADPH oxidase 1 (Nox1) complex.
Prdx6 expression enhances Nox1-derived superoxide production.
The Nox1-supportive effects of Prdx6 involve its phospholipase A2 activity.
Wild-type Prdx6 supports Nox1-mediated migration of colon epithelial cells.