Punica granatum L. mesocarp suppresses advanced glycation end products (AGEs)- and H₂O₂-induced oxidative stress and pro-inflammatory biomarkers

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• 作者：Piteesha Ramlagan^a ; ^b ; Philippe Rondeau^c ; Cynthia Planesse^c ; Vidushi S. Neergheen-Bhujun^a ; ^b ; Shameem Fawdar^b ; Emmanuel Bourdon^c ; ^{emmanuel.bourdon@univ-reunion.fr} ; Theeshan Bahorun^b ; ^{tbahorun@uom.ac.mu}
• 关键词：AAPH ; 2 ; 2&prime ; -azobis(2-amidinopropane) dihydrochloride ; ABTS ; 2 ; 2&prime ; -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) ; AGEs ; advanced glycation end products ; AOPP ; advanced oxidation protein product ; BSAG0 ; native bovine serum albumin ; BSAMGO ; BSA glycated with methylglyoxal ; CAT ; catalase ; DPPH ; 2 ; 2-diphenyl-1-picrylhydrazyl ; FRAP ; ferric reducing antioxidant power ; GPx ; glutathione peroxidase ; IL-6 ; interleukin 6 ; iNOS ; inducible nitric oxide synthase ; MCP-1 ; monocyte chemoattractant
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：115-126
• 全文大小：1263 K
• 卷排序：29

文摘

Effects of PME on oxidative stress and inflammation in 3T3-L1 were assessed. PME decreased ROS production by increasing activities of antioxidant enzymes. PME down regulated NOX1 expression and inhibited oxidative modification of proteins. PME exerted anti-inflammatory effect by decreasing NFκB, iNOS and IL-6 expressions. PME down-regulated mRNA and protein expressions of AGEs receptor CD36.