Rational construction of probes rendering ratiometric response to the cancer-specific enzyme NQO1
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- 作者：Qiang Feia ; b ; Li Zhouc ; Feiyi Wangb ; Ben Shib ; Chunbao Lia ; lichunbao@tju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Rui Wangc ; Chunchang Zhaob ; zhaocchang@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cancer biomarker ; Polymeric micelle ; Nanoprobe ; Ratiometric ; Cancer-specific NQO1
- 刊名：Dyes and Pigments
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：136
- 期：Complete
- 页码：846-851
- 全文大小：1136 K
文摘
- 10">
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10">A new NQO1-responsive small molecule was designed.
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15">Polymeric micelle based nanoprobe was established for the cancer-specific NQO1.
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Ratiometric fluorescence changes of the nanoprobe could be triggered by NQO1.
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Differentiation between NQO1-positive and NQO1-negative cancer cells was obtained.