Impaired hippocampal synaptic plasticity and NR2A/2B expression ratio in remifentanil withdrawal rats
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- 作者：Yi-yi Wanga ; wyiyi70@163.com" class="auth_mail" title="E-mail the corresponding author ; Shichang Liub ; Nan Zhangc ; Jing Yangd ; Yinguo Zhange
- 关键词：Remifentanil withdrawal ; Synaptic plasticity ; Open field test ; Morris water maze ; NR2A/NR2B ; mEPSCs
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：115-123
- 全文大小：798 K
文摘
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The remifentanil addiction and withdrawal rat model was established.
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The remifentanil withdrawal rat exhibited damage of memory and synaptic plasticity.
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Increased hippocampal NR2A/NR2B ratio may participate in the impairment of LTP.
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The changes of basal synaptic transmission may participate in the impairment of LTP.