2,3-dehydrosilybin A/B (DHS A/B) promotes lifespan extension in C. elegans. DHS A/B promotes resistance to stress in human cells and in C. elegans. DHS A/B exerts anti-aggregation properties in human cells and nematodes. DHS A/B leads to decelerated progression of Alzheimer's disease phenotype. DHS A/B outcomes in C. elegans are FGT-1- and DAF-16- dependent.