Influence of immune activation on the risk of allograft rejection in human immunodeficiency virus-infected kidney transplant recipients
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- 作者：Marco A. Lorioa ; 1 ; Rossana Rosab ; 1 ; Jose F. Suareza ; Phillip Ruizc ; Gaetano Ciancioc ; George W. Burkec ; Jose F. Camargob ; jfc31@med.miami.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ART ; antiretroviral therapy ; ATG ; anti-thymocyte globulin ; CMV ; cytomegalovirus ; HIV ; human immunodeficiency virus ; HIVAN ; HIV-associated nephropathy ; INSTI ; integrase strand transfer inhibitor ; IQR ; inter-quartile range ; IVIG ; intravenous immunoglobulin ; PRA ; panel reactive antibody ; PI ; protease inhibitor ; mAb ; monoclonal antibody ; MMF ; mycophenolate mofetil ; NRTI ; nucleoside reverse transcriptase inhibitor ; NNRTI ; non-nucleoside reverse transcriptase inhibitor
- 刊名：Transplant Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：40-43
- 全文大小：236 K
文摘
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First study to examine the role of chronic immune activation on the risk of rejection in HIV+ kidney transplant recipients.
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High levels of activation in HIV+ kidney allograft recipients did not decrease with transplant associated immunosuppression.
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Paradoxically, those individuals with the highest levels of immune activation seemed to be less prone to rejection.
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Pathological immune activation in HIV+ transplant candidates does not explain their increased susceptibility to rejection.