Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy
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- 作者：Raj Kishorea ; b ; raj.kishore@temple.edu" class="auth_mail" title="E-mail the corresponding author ; Prasanna Krishnamurthyc ; Venkata Naga Srikanth Garikipatia ; Cindy Benedicta ; Emily Nickoloffa ; Mohsin Khana ; Jennifer Johnsona ; Anna M. Gumperta ; Walter J. Kocha ; b ; Suresh Kumar Vermaa ; suresh.verma@temple.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：NRVM ; neonatal rat ventricular cardiomyocytes ; Class I PI3K ; class I phosphoinositide 3-kinase ; 4EBP1 ; 4E binding protein 1 ; CHOP ; C/EBP homologous protein ; EF ; ejection fraction ; FS ; fractional shortening ; LY02 ; LY2940002 ; WT ; wild-type
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：part_PB
- 页码：203-213
- 全文大小：2238 K
文摘
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IL-10 deletion exaggerates pathological myocardial autophagy in response to Ang II.
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IL-10 treatment attenuates Ang II-induced pathological autophagy.
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PI3K, Akt or mTORC1 inhibition mitigates IL-10 effect on Ang II-induced autophagy.
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Lysosome inhibition does not alter autophagic flux in IL-10 treated cells.