Synthesis, characterization, in vitro SAR and in vivo evaluation of N,N′bisnaphthylmethyl 2-alkyl substituted imidazolium salts against NSCLC
文摘
A series of N,N′-bisnaphthylmethyl-2-alkyl imidazolium salts was synthesized. Compounds were characterized by 1H and 13C NMR and X-ray crystallography. All compounds reported have high anti-cancer activity comparable to cisplatin. NCI-60 cell line one-dose and five-dose assays. Mechanism of action studies and in vivo toxicity study.