Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
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- 作者：Arsen Petrovic1 ; 6 ; arsen.petrovic@mpi-dortmund.mpg.de" class="auth_mail" title="E-mail the corresponding author ; Jenny Keller1 ; 6 ; Yahui Liu1 ; Katharina Overlack1 ; Juliane John1 ; Yoana N. Dimitrova2 ; Simon Jenni2 ; Suzan van Gerwen1 ; Patricia Stege1 ; Sabine Wohlgemuth1 ; Pascaline Rombaut3 ; Franz Herzog3 ; Stephen C. Harrison2 ; 4 ; Ingrid R. Vetter1 ; ingrid.vetter@mpi-dortmund.mpg.de" class="auth_mail" title="E-mail the corresponding author ; Andrea Musacchio1 ; 5 ; 7 ; andrea.musacchio@mpi-dortmund.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：CENP-C ; KMN network ; Mis12 ; PMF1 ; DSN1 ; NSL1 ; MIND ; kinetochore ; centromere ; CCAN
- 刊名：Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：167
- 期：4
- 页码：1028-1040.e15
- 全文大小：6567 K
文摘
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We report a crystal structure of human MIS12 complex, a crucial kinetochore component
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The structure reveals how the MIS12 complex binds its kinetochore receptor CENP-C
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We dissect how Aurora B kinase promotes the MIS12:CENP-C interaction
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A combination of diverse structural methods reveals outer kinetochore organization