A computational approach to determine susceptibility to cancer by evaluating the deleterious effect of nsSNP in XRCC1 gene on binding interaction of XRCC1 protein with ligase III
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- 作者：Preety Kadian Singh ; Kinnari N. Mistry ; kinnarimistry@aribas.edu.in" class="auth_mail" title="E-mail the corresponding author ; kinnarinmistry@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BER ; base excision repair ; DDG ; Gibbs free energy change ; GO ; gene ontology ; LIG3 ; ligase III ; NER ; nucleotide excision repair ; NHEJ ; non-homologous end joining ; nsSNPs ; non-synonymous single nucleotide polymorphisms ; PDB ; Protein Data Bank ; RI ; reliability index ; SAPs ; single amino acid polymorphisms ; SIFT ; sorting intolerant from tolerant ; subPSEC ; substitution position-specific evolutionary conservation ; SVM ; support vector machine ; XRCC1 ; X-ray repair cross-complementing group 1
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：141-149
- 全文大小：1756 K
文摘
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SNP rs2307166 of XRCC1 protein is predicted to be the most damaging nsSNP.
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Analyses of deleterious effect of SNP on protein structure and functionality
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Docking analysis to study the impact of rs2307166 on XRCC1-LIG3 interactions