Brønsted acid promoted one-pot synthesis of 4-aryl-3,4-dihydrocoumarins

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• 作者：Cheng Chen^b ; Rui Zhang^a ; Long Lin^a ; Guang-Fu Yang^a ; ^{gfyang@mail.ccnu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Qiong-You Wu^a ; ^{qywu@mail.ccnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dihydrocoumarins ; Friedel&ndash ; Crafts alkylation ; Cycloaddition ; Brø ; nsted acid ; Perchloric acid
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：7 July 2016
• 年：2016
• 卷：72
• 期：27-28
• 页码：3917-3921
• 全文大小：563 K

文摘

4-Aryl-3,4-dihydrocoumarins are a class of valuable molecules demonstrating attractive pharmaceutical and biological properties. In this paper, we designed a new and facile approach to synthesis of 4-aryl-3,4-dihydrocoumarin derivatives by Brønsted acid catalyzed Friedel–Crafts alkylation and cycloaddition reaction. With this protocol, 15 examples of 4-aryl-3,4-dihydrocoumarins were successfully prepared with yields ranging from 82 to 99%.