Synthesis of chiral hydantoin derivatives by homogeneous Pd-catalyzed asymmetric hydrogenation

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• 作者：Bao-De Ma^a ; ^b ; Sheng-Hua Du^b ; ; Yu Wang^b ; Xiao-Ming Ou^b ; Ming-Zhi Huang^b ; Li-Xin Wang^a ; Xiao-Guang Wang^b ; ^{wangxg_hnhl@126.com}
• 刊名：Tetrahedron: Asymmetry
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：47-53
• 全文大小：2297 K
• 卷排序：28

文摘

5-Aryl substituted chiral hydantoin derivatives were synthesized via asymmetric hydrogenation of prochiral exocyclic alkenes using a Pd/BINAP catalyst. Moderate to good enantioselectivity were obtained (21–90% ee). A chiral Brönsted acid additive was found to be a key factor to obtain high enantioselectivity.