Phase II randomised trial of autologous tumour lysate dendritic cell plus best supportive care compared with best supportive care in pre-treated advanced colorectal cancer patients
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- 作者：Miguel Caballero-Bañ ; osa ; miguelcaballerobanos@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Daniel Benitez-Ribasb ; Jaime Taberac ; Sara Varead ; Ramon Vilanae ; Luis Bianchie ; Juan Ramó ; n Ayusof ; Mario Pagé ; sf ; Gemma Carrerag ; Miriam Cuatrecasash ; Marta Martin-Richardi ; Joan Cidj ; Miguel Lozanoj ; Antoni Castellsb ; Xabier Garcí ; a-Albé ; nizk ; Joan Maurell ; 1 ; Ramon Vilellaa ; 1
- 关键词：Cancer ; Dendritic cells ; Immunotherapy ; Colorectal ; Vaccine
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：167-174
- 全文大小：527 K
文摘
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This is the first randomised clinical trial in metastatic colorectal cancer patients with autologous dendritic cells.
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In the experimental arm, the frequency of tumour-specific T cells increased.
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We were unable to demonstrate a substantial benefit in progression-free or overall survival compared with best supportive care.