GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function

详细信息    查看全文

• 作者：Maria Christina Sergaki¹ ; Carlos F. Ib&aacute ; &ntilde ; ez¹ ; ² ; ³ ; ⁴ ; ^{carlos.ibanez@ki.se}
• 关键词：cell adhesion ; cerebellum ; development ; GDNF ; RET
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：367-379
• 全文大小：5990 K
• 卷排序：18

文摘

The neurotrophic receptor GFRα1 is transiently expressed in developing Purkinje cells Loss of GFRα1 from Purkinje cells delays their migration The neural cell adhesion molecule NCAM directly interacts with GFRα1 in Purkinje cells Reduction of NCAM expression restores Purkinje cell migration in Gfra1 mutants