文摘
NGF sensitizes rat paw skin to thermal and to mechanical stimulation by separate pathways. Thermal sensitization is triggered via TrkA and mechanical by p75NTR. More distal downstream segments of these receptors show evidence of cross-modulation. Atypical PKCs, e.g., PKMζ, are essential for sensitization to both heat and to touch. The thermo-sensitive TRPV1 receptor also contributes to acute thermal hypersensitivity.