Nurr1 overexpression exerts neuroprotective and anti-inflammatory roles via down-regulating CCL2 expression in both in vivo and in vitro Parkinson's disease models

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• 作者：Wei Liu¹ ; Yang Gao¹ ; Na Chang ; ^{changnachang1@163.com}
• 关键词：Nurr1 ; CCL2 ; Neurodegeneration ; Inflammation ; Parkinson's disease
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1312-1319
• 全文大小：1624 K
• 卷排序：482

文摘

Nurr1 was down-regulated and CCL2 was up-regulated in PD patients and PD mice. Nurr1 overexpression inhibited apoptosis, release of TNF-α and IL-1β and promoted viability in α-Syn-treated SH-SY5Y cells. CCL2 reversed the effect of Nurr1 overexpression on apoptosis, inflammatory cytokines secretion and viability. Nurr1 overexpression negatively regulated CCL2 expression in vivo and in vitro. Nurr1 overexpression remarkably relieved MPTP-induced movement disorder and spatial memory deficits.