Human NUP98-HOXA9 promotes hyperplastic growth of hematopoietic tissues in Drosophila

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• 作者：Caroline Baril^a ; ¹ ; Gwenaë ; lle Gavory^a ; ¹ ; Gawa Bidla^a ; ¹ ; Helene Knæ ; velsrud^a ; Guy Sauvageau^a ; ^b ; Marc Therrien^a ; ^c ; ^{marc.therrien@umontreal.ca}
• 刊名：Developmental Biology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：421
• 期：1
• 页码：16-26
• 全文大小：1705 K
• 卷排序：421

文摘

NUP98-HOXA9 induces leukemia-like phenotypes in Drosophila. The MEIS ortholog HTH collaborates with NUP98-HOXA9 in the fly hematopoietic system. NUP98-HOXA9 interferes with PVR signaling during lymph gland development. NUP98-HOXA9 reveals novel functional interactions between lymph gland compartments.