Alkaloid rich fraction from Nelumbo nucifera targets VSMC proliferation and migration to suppress restenosis in balloon-injured rat carotid artery
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- 作者：Moon Young Juna ; 1 ; Rajendra Karkia ; 1 ; Keshav Raj Paudela ; Bhesh Raj Sharmaa ; Deepak Adhikarib ; Dong-Wook Kima ; mokpou@yahoo.co.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：VSMC ; Proliferation ; Migration ; Restenosis ; Atherosclerosis ; Nelumbo nucifera ; Neferine
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：248
- 期：Complete
- 页码：179-189
- 全文大小：2326 K
文摘
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ARF significantly inhibited intimal thickening in balloon injured carotid artery.
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ARF and its active component neferine inhibited VSMC proliferation and migration.
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Mechanistically, ARF and neferine inhibited NF-κB and MAPKs activation.
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ARF and neferine targeted apical molecule PDGF-Rβ.
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ARF and neferine possessed strong anti-oxidative properties.