Thermodynamics of the formation of Ag(I)-mediated azole base pairs in DNA duplexes
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- 作者：Kristina Schweizera ; J. Christian Lé ; ona ; Bart Jan Ravoob ; Jens Mü ; llera ; mueller.j@uni-muenster.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA ; Isothermal titration calorimetry ; Metal-mediated base pairs ; Nucleobases
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：256-263
- 全文大小：932 K
文摘
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The thermodynamics of Ag(I)-mediated base pair formation were probed by calorimetry.
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Imidazole–Ag(I)–imidazole base pairs are of superior stability.
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Cooperative formation of metal-mediated base pairs may take place.
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The Ag(I)-binding affinity of single imidazole:imidazole pairs is not sequence-dependent.