Activation of cross-reactive mucosal T and B cell responses in human nasopharynx-associated lymphoid tissue in vitro by Modified Vaccinia Ankara-vectored influenza vaccines
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- 作者：Jennifer Mullina ; 1 ; Muhammed S. Ahmeda ; 1 ; Ravi Sharmab ; Navdeep Upileb ; Helen Beerb ; Priya Acharc ; Suttida Puksuriwonga ; Francesca Ferrarad ; Nigel Tempertond ; Paul McNamarae ; Teresa Lambef ; Sarah C. Gilbertf ; Qibo Zhanga ; qibo.zhang@liv.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mucosal immunity ; Influenza vaccine ; Antibody response ; Nasopharynx-associated lymphoid tissue (NALT) ; MVA-vectored vaccine ; Children and adults
- 刊名：Vaccine
- 出版年：2016
- 出版时间：29 March 2016
- 年：2016
- 卷：34
- 期：14
- 页码：1688-1695
- 全文大小：1764 K
文摘
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MVA-vectored influenza vaccines are highly efficient in infecting human NALT.
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Tonsillar B cells are efficient in expressing the encoded vaccine antigen.
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MVA vaccine expressing highly conserved nucleoprotein (NP) elicits T cell response.
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MVA expressing pdmH1N1 HA can induce cross-reactive anti-HA antibodies.
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MVA vaccines may have the potential to be used as intranasal vaccines against influenza.