Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A聽virus H1N1
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- 作者：Meng-I. Lina ; 1 ; Bo-Han Sub ; 1 ; Chia-Hsin Leec ; Suz-Ting Wangc ; Wen-Chun Wuc ; Prasad Dangatec ; Shi-Yun Wanga ; Wen-I. Huanga ; Ting-Jen Chenga ; Olivia A. Lind ; Yih-Shyun E. Chenga ; ; Yufeng Jane Tsengb ; 1 ; yjtseng@csie.ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Chung-Ming Sunc ; 1 ; cmsun@mail.nctu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：RNA-dependent RNA polymerase ; Influenza nucleoprotein ; Anti-influenza ; Pyrimido-pyrrolo-quinoxalinedione (PPQ)
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：18 September 2015
- 年：2015
- 卷：102
- 期：Complete
- 页码：477-486
- 全文大小：2021 K
文摘
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PPQ analogues are a new class of novel anti-influenza agents.
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PPQ analogues inhibit cytoplasmic trafficking of influenza ribonucleoprotein (RNP).
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PPQ inhibits viral protein synthesis at the beginning of H1N1 infection.
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PPQ blocks the RNP nuclear export and aggregation in cytoplasm at later times.
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PPQ interacts to RNP at a distinct NP site different than nucleozin.