Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin
详细信息 查看全文
- 作者：Demetra S.M. Chatzileontiadoua ; 1 ; Vanessa Parmenopouloua ; 1 ; Stella Mantaa ; Anastassia L. Kantsadia ; Paroula Kylindria ; Marianna Griniezakia ; Filitsa Kontopouloua ; Aikaterini Telopouloua ; Helena Prokovaa ; Dimitrios Panagopoulosa ; Ester Boixb ; Nikolaos A.A. Balatsosa ; Dimitri Komiotisa ; dkom@bio.uth.gr" class="auth_mail" title="E-mail the corresponding author ; Demetres D. Leonidasa ; ddleonidas@bio.uth.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：RNase A ; bovine pancreatic ribonuclease A ; PEG ; poly(ethylene glycol) ; TRL2 ; toll-like receptor 2 ; EDN ; eosinophil derived neurotoxin
- 刊名：Bioorganic Chemistry
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：63
- 期：Complete
- 页码：152-165
- 全文大小：2724 K
文摘
- •
Efficient method for the heterologous production and purification of EDN.
- •
Synthesis of two groups of double-headed nucleosides.
- •
Biochemical evaluation of double-headed nucleosides in RNase A and EDN.
- •
Compound 11c displayed a stronger preference for EDN (Ki of 58 μM) than for RNAse A.