Increased levels of adenosine and ecto 5′-nucleotidase (CD73) activity precede renal alterations in experimental diabetic rats
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- 作者：C. Oyarzú ; na ; C. Salinasa ; D. Gó ; meza ; K. Jaramilloa ; G. Pé ; reza ; S. Alarcó ; na ; L. Podestá ; b ; C. Floresc ; C. Quezadaa ; R. San Martí ; na ; rodysanmartin@uach.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diabetic nephropathy ; Adenosine ; 5&rsquo ; -ectonucleotidase ; Urinary biomarkers
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：354-359
- 全文大小：1837 K
文摘
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High adenosine level characterizes incipient diabetic nephropathy.
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Increased CD73 activity in proximal tubules precedes diabetic renal alterations.
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Assessment of urinary CD73 activity is a potential new biomarker of early renal injury.