BMSCs transplantation improves cognitive impairment via up-regulation of hippocampal GABAergic system in a rat model of chronic cerebral hypoperfusion
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- 作者：Q. Longa ; lonva@live.cn" class="auth_mail" title="E-mail the corresponding author ; Y. Heib ; Q. Luoa ; Y. Tiana ; J. Yanga ; J. Lia ; L. Weib ; W. Liub
- 关键词：AD ; Alzheimer&rsquo ; s diseases ; ANOVA ; analysis of variance ; BMSCs ; bone marrow mesenchymal stem cells ; BrdU ; bromo-2-deoxy uridine ; EDTA ; ethylenediaminetetraacetic acid ; GABA ; gamma amino butyric acid ; GABABR1 ; GABAB receptor 1 ; GAD ; glutamic acid decarboxylase ; HCN ; cyclic-nucleotide-gated cation nonselective ; NGF ; nerve growth factor ; PBS ; phosphate-buffered saline ; two-vessel occlusion ; 2VO ; permanent bilateral occlusion of the common carotid arteries ; VaD ; vascular dementia ; VEGF ; vascular
- 刊名：Neuroscience
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：311
- 期：Complete
- 页码：464-473
- 全文大小：3609 K
文摘
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Hippocampal GABAergic system deficit is induced by 2VO procedures.
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Transplantation of BMSCs is able to improve cognitive impairment in a 2VO model.
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Hippocampal GABAergic system expression is up-regulated by BMSC transplantation.