Upregulation of axonal HCN current by methylglyoxal: Potential association with diabetic polyneuropathy
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- 作者：Yoshimitsu Shimatania ; 1 ; Hiroyuki Noderaa ; 1 ; hnodera@tokushima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yusuke Osakia ; Chimeglkham Banzraia ; Kazuhiro Takayasua ; Sachiko Endoa ; Yoshiko Shibutaa ; b ; Ryuji Kajia
- 关键词：AGEs ; advanced glycation end products ; CMAP ; compound muscle action potential ; HCN channel ; hyperpolarization-activated cyclic nucleotide-gated channel ; Ih ; hyperpolarization-activated cation current ; IV ; current&ndash ; threshold relationship ; MGO ; methylglyoxal ; PKC ; protein kinase C ; RC ; recovery cycle ; SDTC ; strength&ndash ; duration time constant ; SNAP ; sensory nerve action potential ; TE ; threshold electrotonus
- 刊名：Clinical Neurophysiology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：126
- 期：11
- 页码：2226-2232
- 全文大小：685 K
文摘
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A metabolic derivative of glucose, methylglyoxal (MGO), has pro-excitatory effects; however, its precise effects on axonal ion channels are not well known.
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There was increased hyperpolarization-activated cation current (Ih) in wild type mice administered with MGO.
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Upregulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) currents might be also present in patients with diabetic neuropathy.