Hypertranscription in Development, Stem Cells, and Regeneration

详细信息    查看全文

• 作者：Michelle Percharde¹ ; Aydan Bulut-Karslioglu¹ ; Miguel Ramalho-Santos¹ ; ^{mrsantos@ucsf.edu}
• 关键词：hypertranscription ; stem cells ; self-renewal ; development ; regeneration ; proliferation ; cell competition ; Myc ; Chd1 ; open chromatin ; cell number normalization
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：9-21
• 全文大小：1935 K
• 卷排序：40

文摘

Cells can globally upregulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Evidence for hypertranscription dates back over 70 years but has gone largely ignored in the genomics era until recently. We discuss data supporting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biology, regeneration, and cell competition. We review the history, methods for analysis, underlying mechanisms, and biological significance of hypertranscription.