Evaluation of the effect of rifampicin on the biophysical properties of the membranes: Significance for therapeutic and side effects
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- 作者：Marina Pinheiro ; marinabppinheiro@gmail.com" class="auth_mail ; Sí ; lvia Pisco ; Ana Sofia Silva ; Clá ; udia Nunes ; Salette Reis
- 关键词：Membrane biophysical studies ; Drug-membrane studies ; Membrane models ; Rifampicin ; Tuberculosis
- 刊名：International Journal of Pharmaceutics
- 出版年：15 May 2014
- 年：2014
- 卷：466
- 期：1-2
- 页码：190-197
- 全文大小：660 K
文摘
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The interactions of rifampicin and macrophage membrane models were evaluated.
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Several biophysical techniques were executed to assess drug-membrane interaction.
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The results confirm that the interactions of RIF with membranes are more pronounced under in vitro pathological conditions.
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This work could lead to the development of new anti-TB drugs with higher efficacy and fewer toxic effects.