Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria
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- 作者：Jing Huanga ; Xiangming Lia ; Jordana G.A. Coelho-dos-Reisa ; Min Zhanga ; b ; Robert Mitchellc ; Raquel Tayar Nogueiraa ; Tiffany Tsaoa ; Amy R. Noed ; Ramses Ayalae ; Vincent Sahia ; Gabriel M. Gutierreze ; Victor Nussenzweiga ; b ; James M. Wilsonf ; Elizabeth H. Nardinc ; Ruth S. Nussenzweigc ; Moriya Tsujia ; mtsuji@adarc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAV9 ; adeno-associated virus serotype 9 ; BAFF ; B cell activation factor ; HIS ; Human immune system ; HSC ; hematopoinetic stem cells ; PfCS ; Plasmodium falciparum cirscumsporozoite
- 刊名：Journal of Immunological Methods
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：427
- 期：Complete
- 页码：42-50
- 全文大小：1346 K
文摘
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Human immune system mice having human CD4 + T and B cells, called HIS-CD4/B mice, were established.
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HIS-CD4/B mice were made by transducing HLA class II and human cytokines via AAV.
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Malaria-specific human CD4 + T-cell and IgG responses were elicited in HIS-CD4/B mice.
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HIS-CD4/B mice can mount protective human anti-malaria immunity.