Helminth-Tuberculosis Co-infection: An Immunologic Perspective

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• 作者：Subash Babup>1p>p> ; p>p>2p>p> ; p>p>sbabu@mail.nih.gov" class="auth_mail" title="E-mail the corresponding authorp> ; Thomas B. Nutmanp>2p>
• 刊名：Trends in Immunology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：37
• 期：9
• 页码：597-607
• 全文大小：1688 K

文摘

Over 2 billion people worldwide are infected with helminths (worms). Similarly, infection with Mycobacterium tuberculosis (Mtb) occurs in over a third of the world's population, often with a great degree of geographical overlap with helminth infection. Interestingly, the responses induced by the extracellular helminths and those induced by the intracellular Mtb are often mutually antagonistic and, as a consequence, can result in impaired (or cross-regulated) host responses to either of the infecting pathogens. In this review, we outline the nature of the immune responses induced by infections with helminths and tuberculosis (TB) and then provide data from both experimental models and human studies that illustrate how the immune response engendered by helminth parasites modulates Mtb-specific responses in helminth–TB coinfection