Genome health nutrigenomics and nutrigenetics – diagnosis and nutritional treatment of genome damage on an individual basis

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• 作者：Michael Fenech
• 关键词：Genome health ; Nutrigenomics ; Nutrigenetics ; DNA damage ; Micronutrients ; Vitamins ; Minerals ; Polymorphisms
• 刊名：Food and Chemical Toxicology
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：46
• 期：4
• 页码：1365-1370
• 全文大小：165 K

文摘

The term nutrigenomics refers to the effect of diet on gene expression. The term nutrigenetics refers to the impact of inherited traits on the response to a specific dietary pattern, functional food or supplement on a specific health outcome. The specific fields of genome health nutrigenomics and genome health nutrigenetics are emerging as important new research areas because it is becoming increasingly evident that (a) risk for developmental and degenerative disease increases with DNA damage which in turn is dependent on nutritional status and (b) optimal concentration of micronutrients for prevention of genome damage is also dependent on genetic polymorphisms that alter function of genes involved directly or indirectly in uptake and metabolism of micronutrients required for DNA repair and DNA replication. Development of dietary patterns, functional foods and supplements that are designed to improve genome health maintenance in humans with specific genetic backgrounds may provide an important contribution to a new optimum health strategy based on the diagnosis and individualised nutritional treatment of genome instability i.e. Genome Health Clinics.