Amelioration of FCA induced arthritis on topical application of curcumin in combination with emu oil
详细信息 查看全文
- 作者：Manish Kumar Jeengar ; M.S.a ; Shweta Shrivastava ; M.S.a ; S. Chandra Mouli Veeravalli ; M.D.b ; V.G.M. Naidu ; Ph.D.a ; Vgmnaidu@niperhyd.ac.in" class="auth_mail" title="E-mail the corresponding author ; Ramakrishna Sistla ; Ph.D.c ; Sistla@iict.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Emu oil ; Curcumin ; Adjuvant induced arthritis ; Inflammation ; Cytokines ; Topical application
- 刊名：Nutrition
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：32
- 期：9
- 页码：955-964
- 全文大小：2105 K
文摘
- •
Curcumin showed highest solubility in emu oil compared to corn oil and water.
- •
Highest skin penetration of curcumin was attained when emu oil was used as a carrier compared to other vehicles (corn oil and water).
- •
Topical application of emu oil containing curcumin reduced inflammation in synergistic fashion in a carrageenan induced paw edema model.
- •
Topically applied curcumin solution with emu oil ameliorated the Freund's complete adjuvant induced arthritis in male Sprague-Dawley rats.