Cd exposure impaired the macronutrient balance and accumulation of lettuce.
High S-SO4 doses to some extent can alleviate Cd toxicity.
S-SO4 partially improves macronutrient status of Cd-exposed lettuce.
Intensive S-SO4 nutrition decreases leaf Cd accumulation in lettuce.
The results could help to develop strategies for limiting Cd bioaccumulation.